About​
Quantitative Biomedicine and Computational Oncoimmunology
Our research groups at the University Medical Center Mainz (UM Mainz) and the German Cancer Research Center (DKFZ) share a common goal: to deepen the understanding of the immune system and its complex interactions within the tumor microenvironment (TME) and other tissue contexts. Anchored in the principles of immunology, bioinformatics, and cancer research, both teams work to uncover mechanisms driving immune regulation and dysfunction.
The Quantitative Biomedicine group, based at the Institute of Immunology at UM Mainz, and the Computational Oncoimmunology team at DKFZ, focus on the computational analysis of high-dimensional data generated through collaborative projects employing advanced single-cell and spatial technologies. Using AI-driven methodologies, we investigate cellular states, spatial dynamics, and molecular interactions to provide insights into immune cell behavior, with a particular interest in regulatory T cells (Tregs) and their roles in health and disease.
While our expertise lies primarily in computational and bioinformatic analysis, these efforts contribute to both basic research and the development of precision medicine approaches. By identifying biomarkers and pathways, we aim to advance fundamental understanding of immune system dynamics while also supporting translational efforts to improve therapeutic strategies for cancer and immune-related diseases.