Quantitative Biomedicine and Computational Oncoimmunology
One research lab, two locations: Our research at the University Medical Center Mainz (UM Mainz) and the German Cancer Research Center (DKFZ) share a common goal: to deepen the understanding of the immune system and its complex interactions within the tumor microenvironment (TME). Anchored in the principles of immunology, bioinformatics, and cancer research, the team works together to uncover mechanisms driving immune regulation and dysfunction.
The team focuses on the computational analysis of high-dimensional data generated through collaborative projects employing advanced single-cell and spatial technologies. Using AI-driven methodologies, we investigate cellular states, spatial dynamics, and molecular interactions to provide insights into immune cell behavior, with a particular interest in regulatory T cells (Tregs) and their roles in health and disease.
While our expertise lies primarily in computational and bioinformatic analysis, these efforts contribute to both basic research and the development of precision medicine approaches. By identifying biomarkers and pathways, we aim to advance fundamental understanding of immune system dynamics while also supporting translational efforts to improve therapeutic strategies for cancer and immune-related diseases.