This list is non-exhaustive. For a complete list, click here. Lab students or co-supervised students are marked in bold.
2025
Identifying similar populations across independent single cell studies without data integration
NAR Genomics and Bioinformatics, Volume 7, Issue 2, June 2025, lqaf042, doi: 10.1093/nargab/lqaf042
Oscar González-Velasco, Malte Simon, Rüstem Yilmaz, Rosanna Parlato, Jochen Weishaupt, Charles D Imbusch, Benedikt Brors
This publication presents ClusterFoldSimilarity (CFS), a method to compare cell groups across independent single-cell datasets without integration. It identifies conserved phenotypes and shared markers, demonstrated in astrocytes from mouse motor cortex and spinal cord.
2024
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
Nat Commun. 2024 Nov 29;15(1):10396. doi: 10.1038/s41467-024-54543-0
Lutz R, Grünschläger F, Simon M, Awwad MHS, Bauer M, Yousefian S, Beumer N, Jopp-Saile L, Sedlmeier A, Solé-Boldo L, Avanesyan B, Vonficht D, Stelmach P, Steinbuss G, Boch T, Steiger S, Baertsch MA, Prokoph N, Rippe K, Durie BGM, Wickenhauser C, Trumpp A, Müller-Tidow C, Hübschmann D, Weinhold N, Raab MS, Brors B*, Goldschmidt H*, Imbusch CD*, Hundemer M*, Haas S*
Long-term survivors of multiple myeloma experience persistent immune alterations, including irreversible “immunological scarring,” driven by inflammatory responses and residual disease activity, even decades after therapy.
Single-Cell Chromatin Accessibility and Transposable Element Landscapes Reveal Shared Features of Tissue-Residing Immune Cells
Immunity. 2024 Aug 13;57(8):1975-1993.e10. doi: 10.1016/j.immuni.2024.06.015
Simon M*, Stüve P*, Schmidleithner L*, Bittner S, Beumer N, Strieder N, Schmidl C, Pant A, Gebhard C, Eigenberger A, Brors B, Imbusch CD, Delacher M, Feuerer M
This publication explores the adaptation mechanisms in tissue-residing immune cells, focusing on regulatory T cells (Tregs) and their chromatin landscapes.
The Effector Program of Human CD8 T Cells Supports Tissue Remodeling
Journal of Experimental Medicine. 2024 Feb 5;221(2):e20230488. doi: 10.1084/jem.20230488
Delacher M*, Schmidleithner L*, Simon M*, Stüve P*, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M
This publication explores the regenerative capabilities of CD8 T cells in tissue remodeling and their implications for tumor biology.
2023
Chronic Chromosome Instability Induced by Plk1 Results in Immune Suppression in Breast Cancer
Cell Reports. 2023 Dec 26;42(12):113266. doi: 10.1016/j.celrep.2023.113266
Kandala S, Ramos M, Voith von Voithenberg L, Diaz-Jimenez A, Choccarro S, Keding J, Brors B, Imbusch CD, Sotillo R.
This study explores the role of chromosome instability in breast cancer and its effect on immune evasion.
2021
Deconvolution of Sarcoma Methylomes Reveals Varying Degrees of Immune Cell Infiltrates With Association to Genomic Aberrations
J Transl Med. 2022 Apr 2;20(1):152. doi: 10.1186/s12967-021-02858-7
Malte Simon, Sadaf S Mughal, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedict Brors, CD Imbusch
This study identifies distinct immune infiltration patterns and genomic alterations in soft-tissue sarcomas through methylation deconvolution.
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells
Immunity. 2021 Apr 13;54(4):702-720.e17. doi: 10.1016/j.immuni.2021.03.007
Delacher M, Simon M, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Schmidleithner L, Bittner S, Pant A, Ritter U, Hehlgans T, Riegel D, Schneider V, Groeber-Becker FK, Eigenberger A, Gebhard C, Strieder N, Fischer A, Rehli M, Hoffmann P, Edinger M, Strowig T, Huehn J, Schmidl C, Werner JM, Prantl L, Brors B, Imbusch CD, Feuerer M
This study identifies a conserved tissue-repair signature in human and murine regulatory T (Treg) cells, revealing a BATF+CCR8+ Treg population in human tissues with regenerative characteristics akin to tumor-resident Tregs, underscoring their role in tissue homeostasis and repair.
Complete Publication List
For a comprehensive overview of all publications, including collaborative works and earlier research contributions, please visit our complete publication database.