Publications
This list is non-exhaustive for a complete list, click here. Lab students or co-supervised students are marked in bold.
2024
Multiple myeloma long-term survivors exhibit sustained immune alterations decades after first-line therapy
Nat Commun. 2024 Nov 29;15(1):10396. doi: 10.1038/s41467-024-54543-0.
Lutz R, Grünschläger F, Simon M, Awwad MHS, Bauer M, Yousefian S, Beumer N, Jopp-Saile L, Sedlmeier A, Solé-Boldo L, Avanesyan B, Vonficht D, Stelmach P, Steinbuss G, Boch T, Steiger S, Baertsch MA, Prokoph N, Rippe K, Durie BGM, Wickenhauser C, Trumpp A, Müller-Tidow C, Hübschmann D, Weinhold N, Raab MS, Brors B*, Goldschmidt H*, Imbusch CD*, Hundemer M*, Haas S*.
Long-term survivors of multiple myeloma experience persistent immune alterations, including irreversible “immunological scarring,” driven by inflammatory responses and residual disease activity, even decades after therapy.
SOX10 Mediates Glioblastoma Cell-State Plasticity
EMBO Reports. 2024 Sep 16. doi: 10.1038/s44319-024-00258-8
Man KH, Wu Y, Gao Z, Spreng AS, Keding J, Mangei J, Boskovic P, Mallm JP, Liu HK, Imbusch CD, Lichter P, Radlwimmer B.
This study investigates the role of SOX10 in glioblastoma, highlighting how its suppression impacts tumor progression through cell-state transition.
Single-Cell Chromatin Accessibility and Transposable Element Landscapes Reveal Shared Features of Tissue-Residing Immune Cells
Immunity. 2024 Aug 13;57(8):1975-1993.e10. doi: 10.1016/j.immuni.2024.06.015
Simon M*, Stüve P*, Schmidleithner L*, Bittner S, Beumer N, Strieder N, Schmidl C, Pant A, Gebhard C, Eigenberger A, Brors B, Imbusch CD, Delacher M, Feuerer M.
This publication explores the adaptation mechanisms in tissue-residing immune cells, focusing on regulatory T cells (Tregs) and their chromatin landscapes.
Diagnostic Leukapheresis Reveals Distinct Phenotypes of NSCLC Circulating Tumor Cells
Molecular Cancer. 2024 May 8;23(1):93. doi: 10.1186/s12943-024-01984-2
Rieckmann LM, Spohn M, Ruff L, Agorku D, Becker L, Borchers A, Krause J, O’Reilly R, Hille J, Velthaus-Rusik JL, Beumer N, Günther A, Willnow L, Imbusch CD, Iglauer P, Simon R, Franzenburg S, Winter H, Thomas M, Bokemeyer C, Gagliani N, Krebs CF, Sprick M, Hardt O, Riethdorf S, Trumpp A, Stoecklein NH, Peine S, Rosenstiel P, Pantel K, Loges S, Janning M.
This study utilizes diagnostic leukapheresis to enrich CTCs from NSCLC patients, enhancing the understanding of CTC heterogeneity.
The Effector Program of Human CD8 T Cells Supports Tissue Remodeling
Journal of Experimental Medicine. 2024 Feb 5;221(2):e20230488., doi: 10.1084/jem.20230488
Delacher M*, Schmidleithner L*, Simon M*, Stüve P*, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Ruhland B, Hofmann V, Bittner S, Ritter U, Pant A, Helbich SS, Voss M, Lemmermann NA, Bessiri-Schake L, Bohn T, Eigenberger A, Menevse AN, Gebhard C, Strieder N, Abken H, Rehli M, Huehn J, Beckhove P, Hehlgans T, Junger H, Geissler EK, Prantl L, Werner JM, Schmidl C, Brors B, Imbusch CD, Feuerer M.
This publication explores the regenerative capabilities of CD8 T cells in tissue remodeling and their implications for tumor biology.
2023
Chronic Chromosome Instability Induced by Plk1 Results in Immune Suppression in Breast Cancer
Cell Reports. 2023 Dec 26;42(12):113266. doi: 10.1016/j.celrep.2023.113266
Kandala S, Ramos M, Voith von Voithenberg L, Diaz-Jimenez A, Chocarro S, Keding J, Brors B, Imbusch CD, Sotillo R.
This study explores the role of chromosome instability in breast cancer and its effect on immune evasion.
2021
Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations
J Transl Med. 2022 Apr 2;20(1):152. doi: 10.1186/s12967-022-03316-8
Malte Simon*, Sadaf S Mughal*, Peter Horak, Sebastian Uhrig, Jonas Buchloh, Bogac Aybey, Albrecht Stenzinger, Hanno Glimm, Stefan Fröhling, Benedikt Brors, CD Imbusch
This study identifies distinct immune infiltration patterns and genomic alterations in soft-tissue sarcomas through methylation deconvolution
Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.
Immunity. 2021 Apr 13;54(4):702-720.e17. doi: 10.1016/j.immuni.2021.03.007.
Delacher M, Simon M, Sanderink L, Hotz-Wagenblatt A, Wuttke M, Schambeck K, Schmidleithner L, Bittner S, Pant A, Ritter U, Hehlgans T, Riegel D, Schneider V, Groeber-Becker FK, Eigenberger A, Gebhard C, Strieder N, Fischer A, Rehli M, Hoffmann P, Edinger M, Strowig T, Huehn J, Schmidl C, Werner JM, Prantl L, Brors B, Imbusch CD, Feuerer M.
This study identifies a conserved tissue-repair signature in human and murine regulatory T (Treg) cells, revealing a BATF+CCR8+ Treg population in human tissues with regenerative characteristics akin to tumor-resident Tregs, underscoring their role in tissue homeostasis and repair.
